Finnhub•2026-04-16
Spyre Therapeutics, Inc. Announces Closing of Public Offering and Full Exercise of the Underwriters’ Option to Purchase Additional Shares for Gross Proceeds of $463.5 MillionSYRE — Spyre Therapeutics Inc
NASDAQ · Biotechnology · Biotechnology
$71.27+105.63%Market cap3.59B
- Latest Close
- $71.27
- 30-Day Move
- +105.6%
- Market Cap
- $3.6B
- Shares Outstanding
- 78,540,000
- P/B Ratio
- 3.55
- ROE
- -21.7%
NASDAQ:SYREBiotechnology / BiotechnologyDelayed public snapshot
Spyre Therapeutics Inc
A read-only Alphactor snapshot forSpyre Therapeutics Inc. It uses the same research structure as the app, but with delayed data and shallow depth so search visitors can evaluate the stock before signing up.
Snapshot as of2026-04-21
Topline snapshot
Latest Close
$71.27
30-Day Move
+105.6%
Market Cap
$3.6B
Shares Outstanding
78,540,000
P/B Ratio
3.55
ROE
-21.7%
Not investment advice. Signals and scores shown here are model outputs derived from historical data, not recommendations. Past performance does not guarantee future results. Do your own research before trading. Full disclaimer
Chart snapshot
$71.27
+105.6%last 90 delayed daily bars
Market cap$3.6B
90D High
$75.00
90D Low
$28.00
Avg Volume
891,943
What stands out
Net margin is -22158.5%, useful for comparing SYRE against peers in Biotechnology.
SYRE is up 105.6% over the last 30 trading days shown on this page.
Latest operating income is $-220M, which helps anchor the headline ratios with an actual earnings figure.
Research snapshot
Rule of 40
-11338.5%
Fundamentals snapshot
Latest Close
$71.27
30-Day Move
+105.6%
Market Cap
$3.6B
Shares Outstanding
78,540,000
P/B Ratio
3.55
ROE
-21.7%
ROA
-20.0%
Operating Margin
-17559.3%
Net Margin
-22158.5%
Debt / Equity
0
Current Ratio
13.25
Latest Revenue
$0
Financial statement snapshot
Revenue
$0
Gross Profit
--
Operating Income
$-220M
Net Income
$-155M
Gross Margin
--
Net Margin
-2215854.0%
Current Ratio
13.25
Debt / Equity
0.00
Quality snapshot
Altman Z
32.57
Safe
Piotroski
2
Weak (0-3)
Cash Conversion
1.09x
Rule of 40
-11338.5%
Concerning
Annual financial history
Annual performance mix
| Period | Revenue | Operating Income | Net Income | Free Cash Flow |
|---|---|---|---|---|
| 2022-12-31 | $2M | $-85M | $-84M | $-80M |
| 2023-12-31 | $886,000 | $-129M | $-339M | $-100M |
| 2024-12-31 | $0 | $-209M | $-208M | $-157M |
| 2025-12-31 | $0 | $-220M | $-155M | $-169M |
After signup
The app opens the full statement deep dive
Extend the history well beyond this public snapshot to inspect longer cycles and regime changes.
Move from summary lines into detailed balance-sheet and cash-flow rows for working capital, debt, and capex analysis.
Cross-link statement changes with alerts, watchlists, and saved research workflows after signup.
News snapshot
Benzinga•2026-04-15
This Cloudflare Analyst Turns Bullish; Here Are Top 4 Upgrades For WednesdayBenzinga•2026-04-15
Reported Earlier, Spyre Therapeutics Prices Upsized Public Offering Of 6.5M Common Shares At $62.00 Per Share For Gross Proceeds Of $403.0MAfter signup
The full sentiment workspace adds context
Go past the public headlines into fuller article history, source cross-checks, and deeper narrative tracking.
Tie news into alerts, watchlists, and conviction changes instead of browsing one static batch of stories.
Insider activity snapshot
Buy Value
$0
Sell Value
$5M
Buys
0
Sells
19
Buy Value
$0
Sell Value
$5M
Buy/Sell Ratio
0.00x
After signup
The full app goes deeper on insider behavior
Inspect longer insider history, recurring buyers and sellers, and the broader transaction context beyond this snapshot.
Continue into deeper institutional and alternative-data views once you sign up.
Recent insider transactions
| Date | Name | Type | Shares | Price |
|---|---|---|---|---|
| 2026-04-01 | Burrows Scott L | M | 7,500 | $0.00 |
| 2026-04-01 | Burrows Scott L | Sell | 1,300 | $49.98 |
| 2026-04-01 | Burrows Scott L | Sell | 6,200 | $49.21 |
| 2026-04-01 | Burrows Scott L | M | 7,500 | $14.50 |
| 2026-04-01 | Turtle Cameron | Sell | 2,656 | $49.92 |
| 2026-04-01 | Turtle Cameron | Sell | 12,344 | $49.20 |
| 2026-04-01 | Sloan Sheldon | M | 7,958 | $0.00 |
| 2026-04-01 | Sloan Sheldon | Sell | 7,958 | $50.00 |
ETF holders snapshot
| ETF | Shares | Weight | As Of |
|---|---|---|---|
| SmallCap World Fund Inc | 3,692,713 | 0.05% | 2025-12-31 |
| Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund | 2,268,205 | 0.03% | 2026-02-28 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2,140,550 | 0.03% | 2025-12-31 |
| iShares Trust-iShares Russell 2000 ETF | 1,670,893 | 0.02% | 2026-02-28 |
| SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF | 1,119,236 | 0.01% | 2026-03-31 |
| Fidelity Select Portfolios-Select Health Care Portfolio | 940,000 | 0.01% | 2026-02-28 |
| T. Rowe Price Health Sciences Fund, Inc. | 896,465 | 0.01% | 2025-12-31 |
| Fidelity Advisor Series VII-Fidelity Advisor Biotechnology Fund | 847,389 | 0.01% | 2026-02-28 |
After signup
The deeper ownership view shows who is leaning in
Open richer institutional and holder diffs to see position changes across filings instead of one static snapshot.
Use those ownership shifts alongside conviction and alerts in the full app workflow.
Institutional holders snapshot
FMR LLC (Fidelity)
Filed 2026-02-17
$381M
+28.5%
Vanguard Group
Filed 2026-01-29
$132M
+32.3%
BlackRock
Filed 2024-08-13
$57M
--
Geode Capital Management
Filed 2026-02-09
$54M
+35.4%
Charles Schwab
Filed 2026-02-13
$19M
+35.1%
Northern Trust
Filed 2026-02-17
$18M
+26.9%
For informational and educational purposes only. Not financial advice. Learn more
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